Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 159

Conference Videos 8

Year

2024 1

2023 8

2022 23

2021 17

2020 8

2019 19

2018 7

2017 10

2016 3

2015 10

2014 12

2013 6

2012 7

2011 1

2010 10

2009 2

2008 4

2007 8

2006 2

2005 1

open ︾

Keywords

sensitivity analysis 27

drug delivery 12

drug resistance 8

sensitivity 8

multi-objective optimization 4

robust design 4

Drug discovery 3

Sobol’s sensitivity indices 3

cancer 3

nanotechnology 3

Artificial intelligence 2

Box-Behnken method 2

load growth 2

load models 2

nanomedicine 2

reliability sensitivity 2

reliability-based design optimization 2

reliability-based sensitivity analysis 2

targeted therapy 2

open ︾

Search scope:

排序： Display mode:

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: The sensitivity of two murine ascites hepatocarcinoma cell lines (Hca-P and Hca-P/L ) and two anchorage-dependent

Keywords： murine ascites hepatocarcinoma cell line metastasis curcumin drug sensitivity

HTML PDF Collect

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, weThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given withcurative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectivelyThis concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and

Keywords： cancer drug resistance genetic screens senescence targeted therapy

HTML PDF Collect

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

HTML PDF Collect

Research on acoustic-structure sensitivity using FEM and BEM

ZHANG Jun, ZHAO Wenzhong, ZHANG Weiying

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 1, Pages 62-67 doi: 10.1007/s11465-007-0010-1

Abstract: Acoustic-structure sensitivity is used to predict the change of acoustic pressure when a structure designThe sensitivity is significant for reducing noise of structure.Using FEM (finite element method) and BEM (boundary element method) acoustic-structure sensitivity wasThen, acoustic-structure sensitivity was computed by linking velocity sensitivity in FEM and acousticsensitivity in BEM.

Keywords： sensitivity method BEM acoustic pressure pressure sensitivity frequency

HTML PDF Collect

Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering improved pressure aqueous technique

HTML PDF Collect

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release drug delivery semi-solids polymer excipient

HTML PDF Collect

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite hollow spheres synthesis drug release

HTML PDF Collect

Parametric sensitivity analysis of cellular diaphragm wall

Xi CHEN, Wei XU

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 4, Pages 358-364 doi: 10.1007/s11709-012-0177-3

Abstract: The results indicated that the maximum lateral displacement, which is the evaluation index of sensitivity

Keywords： cellular diaphragm wall sensitivity analysis optimization centrifuge model test

HTML PDF Collect

Probability strength design of steam turbine blade and sensitivity analysis with respect to random parameters

DUAN Wei

Frontiers in Energy 2008, Volume 2, Issue 1, Pages 107-115 doi: 10.1007/s11708-008-0018-1

Abstract: Probability sensitivity analysis, which combines the slope of the gradient and the width of the scatter

Keywords： Probability sensitivity sensitivity analysis number cross-section statistical

HTML PDF Collect

Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China

HTML PDF Collect

Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesEach was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effectsThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyThe clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease

HTML PDF Collect

Wheel tracking methods to evaluate moisture sensitivity of hot-mix asphalt mixtures

Jie HAN,Harihar Shiwakoti

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1, Pages 30-43 doi: 10.1007/s11709-016-0318-1

Abstract: Existing test methods to determine moisture sensitivity in hot-mix asphalt (HMA) mixtures are time consumingThis research focused on wheel tracking devices to evaluate moisture sensitivity.The HWTD test is more effective as a rapid test method in case of determining moisture sensitivity.

Keywords： hot-mix asphalt moisture sensitivity rutting wheel tracking test

HTML PDF Collect

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:

HTML PDF Collect

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4, Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Keywords： bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch

HTML PDF Collect

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4, Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

Keywords： drug delivery platelets nanomedicine bio-inspired biomimetic